4-METHYL-OXAZOLE-5-CARBOXYLIC ACID
4-Methyl-1,3-Oxazole-5-Carboxylic Acid
CAS: 2510-32-9
Molecular Formula: C5H5NO3
4-METHYL-OXAZOLE-5-CARBOXYLIC ACID - Names and Identifiers
4-METHYL-OXAZOLE-5-CARBOXYLIC ACID - Physico-chemical Properties
| Molecular Formula | C5H5NO3 |
| Molar Mass | 127.1 |
| Density | 1.348±0.06 g/cm3(Predicted) |
| Melting Point | 239 °C |
| Boling Point | 267.3±20.0 °C(Predicted) |
| pKa | 2.09±0.31(Predicted) |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| MDL | MFCD01571070 |
4-METHYL-OXAZOLE-5-CARBOXYLIC ACID - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S22 - Do not breathe dust. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| WGK Germany | 3 |
| HS Code | 29349990 |
| Hazard Note | Irritant |
4-METHYL-OXAZOLE-5-CARBOXYLIC ACID - Reference Information
| Application | 4-methyl-5-formyl-1, 3-oxazole can be used as organic intermediates and pharmaceutical intermediates, mainly used in laboratory research and development process and chemical medicine analysis process. |
| preparation | sodium hydroxide (58.04g,1.45 mol) was added to 4-methyl -1 in 3 batches at room temperature, ethyl 3-oxazole-5-carboxylate 1.2 mo in water: methanol: THF(1 : 1: 1,1.5 L) over 40 min, the reaction was mechanically stirred for 4 h. TLC (developing solvent and 5) showed that the reaction was complete. Distilled off methanol under reduced pressure, with water (1 L) Dissolve the concentrate, add Amberlite IR-120 cation exchange resin (, stack volume, light yellow spheres), stir, white solid (product ) precipitated, pour out the upper suspension; the bottom resin was stirred again with water, and the upper suspension was poured out. The suspensions were combined, suction filtered, the filter cake was washed with diethyl ether (about 300 ml), and dried to give a white solid 1(445g,92% ), purity 99% [HPLC normalization method: column Purospher®STAR RP-18 column (4.6 × 250 mm,5 µm); Mobile phase: 0.02 mol/L sodium dihydrogen phosphate solution (adjusted to pH 3.0 with phosphoric acid): acetonitrile (30 ∶ 70); flow rate 1.0 ml/min ; Detection wavelength 229 nm; Column temperature 25 ℃]. |
Last Update：2024-04-09 21:31:59
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